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When we talk about hormone replacement therapy (HRT), estrogen often gets all the attention—but progesterone is just as important. For women navigating perimenopause, menopause, or even post-hysterectomy hormone optimization, progesterone plays a vital and multifaceted role in protecting the body and supporting whole-person wellness. Here’s why progesterone is essential in a balanced HRT plan: 1. Protects the Uterus If you still have a uterus, progesterone is non-negotiable. Estrogen alone can cause the uterine lining to thicken excessively, increasing the risk of endometrial hyperplasia and even cancer. Progesterone keeps that lining in check by opposing estrogen’s proliferative effects, offering critical protection.  2. Balances Estrogen Dominance Progesterone works in harmony with estrogen to keep your hormone levels in balance. Without it, estrogen dominance can creep in—bringing symptoms like bloating, mood swings, anxiety, breast tenderness, and stubborn weight gain. A properly dosed progesterone regimen helps neutralize this imbalance. 3. Regulates the Menstrual Cycle For those still cycling or in perimenopause, progesterone is essential for triggering healthy, predictable periods. It prepares the body for a potential pregnancy and, when levels fall, initiates menstruation—keeping your cycle regulated and your hormones in sync. 4. Strengthens Bones We often talk about estrogen’s role in bone density, but progesterone deserves credit too. It stimulates osteoblast activity—the cells responsible for building bone. Together, these hormones are key to maintaining skeletal strength as we age. 5. Supports Sleep and Mood If you’ve ever felt more anxious, irritable, or sleep-deprived during your luteal phase (the second half of your cycle), you’ve felt the effects of dropping progesterone. Progesterone acts on GABA receptors in the brain to calm the nervous system. The result? Better mood stability, reduced anxiety, and more restorative sleep. 6. Supports Breast Health Estrogen can stimulate breast tissue growth, which—if unbalanced—may increase discomfort or risk over time. Progesterone helps moderate this stimulation, promoting healthier, more comfortable breast tissue. 7. Improves Estrogen Tolerance Progesterone often reduces side effects from estrogen therapy—like breast tenderness and water retention—making the entire HRT experience more tolerable and effective. 8. May Benefit the Cardiovascular System While research is still evolving, some studies suggest progesterone has vasodilatory effects that can support healthy blood flow and vascular tone—hinting at cardioprotective potential. At JaeNix Med Spa & Wellness Lounge , we tailor HRT plans to your individual labs, goals, and symptoms—always prioritizing balance, protection, and optimization. Whether you're newly navigating menopause or fine-tuning an existing protocol, progesterone isn’t optional—it’s essential. 📞 Ready to explore your personalized hormone plan? Book a discovery call today.

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Feeling tired, moody, or off? Learn the difference between normal and optimal hormone levels in women. Discover how hormone therapy in Plano, TX can help you feel like yourself again.

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